Pocket street guides were published in the late-19th to the mid-20th centuries by popular medicine purveyors in most large American cities. They included useful information for the newcomer or visitor, such as the baseball schedule and bus routes, and were tailored to the demographics of each city, including being translated into the languages of the largest non-English speaking populations. The guides also included advice on avoiding and, failing that, treating venereal disease. Directions to the office of a physician (and the likely publisher of the guide) who specialized in these sensitive treatments were provided, as well as an explanation of the available remedies, the evolution of which can be tracked through these guides. From about 1910, references are typically made to ‘606’ and ‘914’ – injectable arsenical compounds – until they were completely eclipsed by the miraculous penicillin, in common use by the 1940s.